https://link.springer.com/article/10.1007%2Fs00203-020-02007-6
https://doi.org/10.1007/s00203-020-02007-6
https://pubmed.ncbi.nlm.nih.gov/32749661/
TITLE:
Comparative analysis of the gut microbiota composition in the Cln1(R151X) and Cln2(R207X) mouse models of Batten disease and in three wild-type mouse strains
ALTERNATIVE TITLE:
None
DATE:
Tue, 04 Aug 2020 06:00:00 -0400
AUTHORS:
Camille Parker,Jing Zhao,David A Pearce,Attila D Kovács
SOURCE:
Archives of microbiology
DESCRIPTION:
Accumulated evidence indicates that the gut microbiota affects brain function and may be altered in neurological diseases. In this study, we analyzed the gut microbiota in Cln1^(R151X) and Cln2^(R207X) mice, models of the childhood neurodegenerative disorders, infantile CLN1 and late infantile CLN2 Batten diseases. Significant alterations were found in the overall gut microbiota composition and also at the individual taxonomic ranks as compared to wild-type mice. The disease-specific alterations…
CONTENT:
Arch Microbiol. 2020 Aug 4. doi: 10.1007/s00203-020-02007-6. Online ahead of print.
ABSTRACT
Accumulated evidence indicates that the gut microbiota affects brain function and may be altered in neurological diseases. In this study, we analyzed the gut microbiota in Cln1R151X and Cln2R207X mice, models of the childhood neurodegenerative disorders, infantile CLN1 and late infantile CLN2 Batten diseases. Significant alterations were found in the overall gut microbiota composition and also at the individual taxonomic ranks as compared to wild-type mice. The disease-specific alterations in the gut microbiota of Cln1R151X and Cln2R207X mice may contribute to the disease phenotypes observed in these mouse models. We also compared the gut microbiota composition of three wild-type mouse strains frequently used in transgenic studies: 129S6/SvEv, C57BL/6J and mixed 129S6/SvEv × C57BL/6J. Our results show that the gut microbiota of 129S6/SvEv and C57BL/6J mice differs remarkably, which likely contributes to the known, pronounced differences in behavior and disease susceptibility between these two wild-type mouse strains.
PMID:32749661 | DOI:10.1007/s00203-020-02007-6
PUBMED ID:
pubmed:32749661
OTHER ID:
pmid:32749661,doi:10.1007/s00203-020-02007-6
PUBLICATION DATE:
Tue, 04 Aug 2020 06:00:00 -0400
2020-08-05
RETRIEVAL DATE :
08/04/20 07:05PM
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/32749661/?utm_source=MS-Office&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1nWYA0Nnwr_wLHWsIDX2btUvlzF91Kc2m_rAz6Uc2Ke1bh4s-l&fc=20200622115739&ff=20200804190540&v=2.11.4
LINK – DOI:
https://doi.org/10.1007/s00203-020-02007-6
LINK – FULL TEXT:
Pending
NOTES:
None